Manchester City manager Roberto Mancini is convinced his side will suffer no lasting effects from their weekend derby defeat.
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A wonder goal from Wayne Rooney gave Manchester United victory at Old Trafford on Saturday after David Silva had cancelled out Nani's opener for the home side.
Manchester City supporters are growing increasingly confident Mancini's side can become history-makers and they can start in this game against a home side who hold a staggering 40-year unbeaten record in Europe, spanning 24 games, and that has seen the likes of Chelsea fail to win in Thessalonika in recent times.
They therefore face a difficult challenge to end that run but bigger games and tougher tests surely lying ahead in this competition.
Yet after making heavy work of progressing through the group stages and into the last 32 of the Europa League, Mancini can't take this trip too lightly.
"It is a challenge for our players to produce their best and I think they will. If you are afraid, you cannot face anyone. The value of Manchester City is great, but we will not win if we play in fear."
Leading scorer Carlos Tevez is included in City's squad even though he has rarely featured in the competition this season, as is Mario Balotelli following a knee problem.
New signing Edin Dzeko also travelled with the squad as did Jo, who has found himself further down the pecking order.
